Loading...
1 / 2
GHK-CU
Add to Wishlist
Copper Peptide Complex for Tissue Regeneration and Skin Renewal
In Stock
Select Size
$70.00$84.00
You Save
$14.00In Stock — Ships Same Day
Includes
50mg research compound
Third-party lab tested
Free shipping on orders over $150
30-day money-back guarantee
Overview
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide with a high affinity for copper(II) ions, first isolated from human plasma in 1973 by Dr. Loren Pickart. Present at approximately 200 ng/mL in young plasma, GHK-Cu levels decline significantly with age, dropping to roughly 80 ng/mL by age 60. At the molecular level, GHK-Cu modulates gene expression across multiple pathways, with microarray studies demonstrating that it influences the activity of over 4,000 human genes, notably upregulating collagen I, collagen III, elastin, decorin, and several glycosaminoglycans critical for extracellular matrix integrity. Published peer-reviewed research indicates that GHK-Cu activates wound healing through stimulation of dermal fibroblast proliferation, promotion of angiogenesis via VEGF and FGF-2 upregulation, and recruitment of mesenchymal stem cells to injury sites. Its antioxidant profile includes potent superoxide dismutase (SOD)-like activity and suppression of iron-catalyzed lipid peroxidation and free radical damage. What distinguishes GHK-Cu from other regenerative peptides is its dual role as both a remodeling signal and an anti-inflammatory modulator — it simultaneously promotes new tissue formation while downregulating genes associated with fibrinogen synthesis and acute inflammatory responses, including TGF-beta and TNF-alpha pathways. Current scientific investigation continues in areas of dermal rejuvenation, hair follicle cycling, chronic wound repair, and COPD-related lung tissue remodeling, with multiple in-vivo and in-vitro studies published across independent laboratories worldwide.
Handling & Storage
Published research protocols reference subcutaneous and topical administration routes. Store refrigerated at 2-8°C.
Published Research Protocols
Published research protocols reference 1-2mg daily subcutaneous or topical application twice daily. Consult applicable literature for specific research applications.
Research Applications
Collagen Synthesis
Published research demonstrates that GHK-Cu upregulates collagen type I and type III synthesis in dermal fibroblasts by activating TGF-beta signaling and increasing decorin expression, which organizes collagen fibril assembly. Microarray studies show simultaneous increases in elastin and glycosaminoglycan production, restoring the extracellular matrix architecture that degrades with chronological and photoaging.
Initial effects within first month
Wound Healing
GHK-Cu activates multiple convergent wound repair pathways, including fibroblast and keratinocyte migration, angiogenesis through VEGF and FGF-2 upregulation, and nerve outgrowth at injury margins. Preclinical wound models report significantly accelerated closure rates, increased granulation tissue formation, and reduced hypertrophic scarring compared to untreated controls, with proposed mechanisms involving mesenchymal stem cell recruitment to injury sites.
Initial effects within first month
Research Studies
Antioxidant Protection
GHK-Cu exhibits potent superoxide dismutase (SOD)-like enzymatic activity, directly catalyzing the dismutation of superoxide radicals. Additionally, it suppresses iron-catalyzed lipid peroxidation and inhibits reactive carbonyl species formation, protecting cell membranes and mitochondrial function from oxidative stress. Published literature suggests it also upregulates endogenous antioxidant enzyme gene expression, amplifying cellular defense capacity beyond its direct radical-scavenging activity.
Initial effects within first month
Research Studies
Frequently Asked Questions
How should I store this peptide?
GHK-Cu in lyophilized form should be stored at -20°C, where it remains stable for up to 24 months. The copper ion complex is relatively robust, but exposure to moisture can cause premature degradation. Once reconstituted with bacteriostatic water, store at 2-8°C protected from light and use within 30 days. Note that GHK-Cu solutions may develop a faint blue-green tint from the copper complex — this is normal and indicates intact copper coordination.
What purity level is this product?
Our GHK-Cu is verified at 99%+ purity through independent HPLC analysis at Janoshik Analytical Laboratory. Each batch undergoes additional mass spectrometry testing to confirm the molecular identity of the copper-peptide complex (MW 403.93 Da), along with elemental copper content analysis to verify proper metal coordination stoichiometry. Certificates of Analysis are available for every batch.
How is the dosage calculated for the 30-day supply?
GHK-Cu vial quantities are formulated based on dosage ranges cited in published peer-reviewed research, typically 1-2mg daily for subcutaneous protocols. The 50mg vial supports lower-dose research designs, while the 100mg vial accommodates higher-dose or extended protocols referenced in the dermal regeneration and wound healing literature.
Do you ship internationally?
Currently we ship to all 50 US states with free standard shipping. Express shipping (2-3 business days) is available for $9.99. GHK-Cu ships as a stable lyophilized powder and tolerates standard shipping conditions well. International shipping is coming soon.
Is this product for human use?
GHK-Cu is sold strictly for in-vitro research, laboratory use, and educational purposes. While GHK-Cu is a naturally occurring human plasma peptide with a substantial body of published research including clinical dermatological studies, this product is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
Important Notice
Not for human consumption. This product is sold exclusively for in-vitro research and laboratory use. It is not a drug, supplement, food item, or cosmetic and has not been evaluated by the FDA.
The research data and clinical references cited on this page are provided for educational reference only and do not constitute medical advice. This product must be handled by qualified research professionals in accordance with all applicable institutional and regulatory guidelines.
Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
Research Articles
Published research and educational content related to GHK-CU
Research12 min read
Semaglutide: A Comprehensive Research Guide to GLP-1 Receptor Agonists
An in-depth exploration of semaglutide research, covering its development history, GLP-1 receptor mechanism, pharmacokinetics, and how it compares to other incretin-based peptides in published studies.
Dr. James ParkResearch Analyst
Research11 min read
BPC-157 vs TB-500: Comparing Recovery Research Peptides
A detailed comparison of two of the most studied recovery peptides in preclinical research, examining their distinct mechanisms, published findings, and how investigators approach studying them individually and in combination.
Dr. Sarah ChenChief Science Officer
Research12 min read
Growth Hormone Secretagogues: CJC-1295, Ipamorelin, GHRP-2 & GHRP-6 Research Overview
A comprehensive research overview of the major growth hormone secretagogues, including GHRH analogs and ghrelin receptor agonists, their mechanisms of action, selectivity profiles, and published preclinical and clinical findings.
Dr. James ParkResearch Analyst
Research14 min read
Immune-Modulating Peptides: Thymosin Alpha-1, LL-37, and KPV Research
An overview of three key peptides being studied for their immune-modulating properties, covering innate and adaptive immune mechanisms, published research findings, and the current state of immunopeptide science.
Michael TorresContent Director
