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AOD9604
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Growth Hormone Fragment Studied for Lipolytic Activity
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5mg
$75.00$90.00
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5mg research compound
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Overview
AOD-9604 is a synthetic peptide fragment corresponding to amino acids 176-191 of human growth hormone, with an additional tyrosine residue at the N-terminus to enhance stability. This 16-amino acid modified fragment was specifically engineered to isolate the lipolytic activity of HGH from its growth-promoting and diabetogenic effects. Research published in the Journal of Endocrinology demonstrated that AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue by mimicking the fat-metabolizing region of growth hormone without activating the GH receptor's JAK2/STAT5 signaling cascade responsible for IGF-1 elevation. Preclinical studies in obese animal models showed significant reductions in body fat without changes in blood glucose levels, food intake, or lean body mass. What distinguishes AOD-9604 from full-length HGH or other GH secretagogues is its inability to raise IGF-1 or induce insulin resistance, making it a focused research tool for studying lipolytic mechanisms independent of growth signaling. AOD-9604 received GRAS (Generally Recognized As Safe) status from the FDA as a food supplement ingredient, though this PEPCELL product is a research-grade compound sold exclusively for laboratory investigation.
Handling & Storage
Published research protocols reference daily subcutaneous administration. Store refrigerated at 2-8°C. Consult applicable literature for specific research applications.
Published Research Protocols
Published research protocols reference 250-300mcg daily in 12-week cycles. Consult applicable literature for specific research applications.
Research Applications
Targeted Fat Loss
Stimulates lipolysis specifically in adipose tissue by mimicking the fat-metabolizing C-terminal region of growth hormone. Published research in obese Zucker rats demonstrated significant reductions in body fat mass without concurrent changes in lean tissue or overall food consumption.
Initial effects within first month
Research Studies
Lipogenesis Inhibition
Inhibits the formation of new fat cells and prevents lipid storage through suppression of lipogenic enzyme activity. This dual action — promoting fat breakdown while blocking fat synthesis — has been documented in multiple preclinical models as a mechanism distinct from caloric restriction.
Initial effects within first month
Research Studies
No IGF-1 Increase
Does not activate the JAK2/STAT5 signaling pathway responsible for IGF-1 production, insulin resistance, or tissue growth. This selectivity was confirmed in studies showing no elevation of circulating IGF-1 levels or blood glucose changes, even at doses producing significant lipolytic effects.
Initial effects within first month
Research Studies
Frequently Asked Questions
How does AOD-9604 differ from full-length HGH?
AOD-9604 is a 16-amino acid fragment corresponding to the C-terminal fat-metabolizing region of human growth hormone (residues 176-191). Unlike full-length HGH, it does not activate the GH receptor's growth signaling cascade, does not raise IGF-1 levels, and does not affect blood glucose or promote tissue growth. It isolates only the lipolytic activity of growth hormone.
What does GRAS status mean for AOD-9604?
AOD-9604 received Generally Recognized As Safe (GRAS) status from the FDA as a food supplement ingredient. This designation reflects safety evaluation data but does not constitute FDA approval as a drug. The PEPCELL product is a research-grade compound intended for laboratory investigation, not dietary supplementation.
How should AOD-9604 be reconstituted?
Add bacteriostatic water slowly along the vial wall, allowing the lyophilized peptide to dissolve without agitation. AOD-9604 is a relatively stable small peptide fragment, but avoid shaking to preserve structural integrity. Once reconstituted, refrigerate at 2-8°C and use within 30 days.
What purity testing is performed on AOD-9604?
Each AOD-9604 batch is independently tested at Janoshik Analytical Laboratory using HPLC for purity determination and mass spectrometry for identity verification. Current batches test at 99.8% purity, with full Certificates of Analysis available on the product page.
Is AOD-9604 intended for human use?
This AOD-9604 product is sold exclusively for in-vitro research, laboratory investigation, and educational purposes. It is not an FDA-approved drug and is not intended for human consumption or self-administration. Researchers should review all applicable regulations before use.
Important Notice
Not for human consumption. This product is sold exclusively for in-vitro research and laboratory use. It is not a drug, supplement, food item, or cosmetic and has not been evaluated by the FDA.
The research data and clinical references cited on this page are provided for educational reference only and do not constitute medical advice. This product must be handled by qualified research professionals in accordance with all applicable institutional and regulatory guidelines.
Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.