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Size: 500mg
Cellular Peptide
In stock · Ships same day · Free shipping over $150
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a 663 Da dinucleotide coenzyme present in every living cell, functioning as an essential electron carrier in over 500 enzymatic redox reactions including glycolysis, the TCA cycle, and oxidative phosphorylation that collectively generate the majority of cellular ATP. Beyond its metabolic role, NAD+ serves as the obligate co-substrate for three critical families of signaling enzymes: sirtuins (SIRT1-7), which are NAD+-dependent deacetylases and ADP-ribosyltransferases that regulate DNA repair, mitochondrial biogenesis, inflammation, and cellular stress resistance; PARPs (poly-ADP-ribose polymerases), which consume NAD+ during DNA damage repair; and CD38/CD157 ectoenzymes involved in calcium signaling and immune cell function. Published peer-reviewed literature demonstrates that NAD+ levels decline by approximately 50% between ages 40 and 60 across multiple human tissue types, driven by increased CD38 expression, elevated PARP activity from accumulating DNA damage, and reduced salvage pathway synthesis. Injectable NAD+ provides direct systemic delivery of the intact coenzyme, bypassing the multi-step enzymatic conversion required for oral precursors (NMN, NR) to generate intracellular NAD+ through the salvage pathway. What distinguishes injectable NAD+ from oral precursor supplementation is its immediate bioavailability and the ability to rapidly elevate circulating and tissue NAD+ levels without rate-limiting enzymatic conversion steps. Current scientific investigation spans metabolic dysfunction, neurodegenerative disease, cardiac ischemia-reperfusion injury, immune aging (immunosenescence), and the broader role of the NAD+ metabolome in the biology of aging.
NAD+ is the essential electron acceptor in mitochondrial Complex I (NADH dehydrogenase), the entry point of the electron transport chain that generates the proton gradient driving ATP synthesis. Published research demonstrates that age-related NAD+ decline directly impairs mitochondrial oxidative phosphorylation efficiency, and that restoring NAD+ levels rescues Complex I activity, reduces electron leak, and improves cellular ATP output in models of aging and metabolic dysfunction.
NAD+ serves as the obligate co-substrate for PARP enzymes that detect and repair DNA single-strand breaks, and for sirtuin deacetylases (particularly SIRT1 and SIRT3) that regulate DNA repair gene expression, mitochondrial biogenesis, and inflammatory NF-kB signaling. Published research demonstrates that NAD+ depletion creates a competitive substrate deficit between PARPs and sirtuins, impairing both DNA repair capacity and longevity-associated sirtuin activity simultaneously.
Preclinical research demonstrates that NAD+ replenishment supports neuronal health through activation of SIRT1-mediated neuroprotective pathways, enhanced mitochondrial function in metabolically demanding neurons, and improved cerebrovascular endothelial function for brain perfusion. Published studies in aged mouse models report improvements in neurovascular coupling, synaptic plasticity markers, and cognitive performance following NAD+ level restoration.
Published research protocols reference IV infusion and subcutaneous administration routes. Store refrigerated at 2-8°C. Consult applicable literature for specific research applications.
Every batch is independently analyzed by a third-party laboratory for purity and identity before release. A batch-specific Certificate of Analysis (COA) is available for each lot.
Purity
99.6%
Lab
Janoshik Analytical Laboratory
Batch
NAD-2024-005
Test Date
2024-12-10T00:00:00Z
Orders placed before our daily cutoff ship the same business day. Free shipping on orders over $150, with tracking emailed as soon as your order leaves our facility.
Shipment protection covers your order against loss or damage in transit — if a protected order is lost or arrives damaged, our support team will arrange a replacement or resolution.
For in-vitro research and laboratory use only. This product is not a drug, supplement, food, or cosmetic, and has not been evaluated by the FDA.
Use is restricted to qualified researchers and laboratories operating within all applicable institutional, legal, and ethical guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
Our NAD+ is pharmaceutical-grade nicotinamide adenine dinucleotide manufactured in FDA-registered, cGMP-compliant facilities. Each batch undergoes HPLC purity analysis (99%+), UV spectrophotometric verification of the characteristic 260nm absorption peak, and enzymatic activity assay to confirm the oxidized (active) NAD+ form rather than reduced NADH. Sterility and endotoxin testing ensure suitability for injectable research protocols.
NAD+ in lyophilized form stored at -20°C protected from light and moisture remains stable for up to 24 months. NAD+ is a dinucleotide coenzyme that is susceptible to hydrolysis and photodegradation, particularly in aqueous solution. Once reconstituted, store at 2-8°C in amber vials and use within 14 days. The 663 Da molecule is significantly more labile than most peptides, so prompt use of reconstituted solutions is recommended.
Each order includes NAD+ at the specified dosage in lyophilized form, a Certificate of Analysis (COA) from Janoshik Analytical Laboratory confirming purity and oxidized-state identity, and detailed storage and reconstitution instructions. The 500mg vial supports subcutaneous research protocols, while the 1000mg vial accommodates higher-dose or IV infusion study designs referenced in the published literature. Sterile water or bacteriostatic water for reconstitution is sold separately.
Yes, we offer volume discounts for research institutions and bulk orders of NAD+. Given the broad research interest in NAD+ biology spanning longevity, neuroscience, cardiology, and metabolic research, we accommodate both standard and large-scale study requirements. Contact support@pepcelllabs.com for wholesale pricing and custom quantities.
This NAD+ product is sold strictly for in-vitro research, laboratory use, and educational purposes. While NAD+ IV infusion clinics operate in many jurisdictions and human clinical trials investigating NAD+ supplementation are ongoing, this specific research-grade product is not a pharmaceutical preparation and is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
