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Size: 10mg
Cellular Peptide
In stock · Ships same day · Free shipping over $150
Technical specifications
Molecular Profile
Mitochondria-targeting tetrapeptide (elamipretide).
Storage Requirements
Lyophilized (powder)
-20°C · stable long-term
Reconstituted / in solution
2-8°C · use within 30 days
SS-31 (elamipretide, also designated Bendavia and MTP-131) is a synthetic cell-permeable tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2 that selectively concentrates approximately 5,000-fold within the inner mitochondrial membrane (IMM) driven by the large electrochemical potential gradient across the IMM. At the molecular level, SS-31 binds selectively to cardiolipin, a unique bis-phosphatidylglycerol phospholipid found exclusively in the IMM that is essential for the structural organization of electron transport chain (ETC) supercomplexes and the activity of cytochrome c oxidase (Complex IV) and ATP synthase (Complex V). Published peer-reviewed research demonstrates that cardiolipin undergoes peroxidative damage with aging and in metabolic disease, leading to ETC disorganization, electron leak, excessive reactive oxygen species (ROS) production, and impaired ATP synthesis — a vicious cycle of mitochondrial decline. By stabilizing cardiolipin's interaction with ETC complexes, SS-31 restores supercomplex assembly, improves electron transfer efficiency, reduces ROS generation at the source rather than scavenging it downstream, and enhances ATP output. What distinguishes SS-31 from conventional antioxidants is its targeted accumulation at the precise mitochondrial site of ROS generation, addressing the cause rather than the consequence of mitochondrial oxidative stress. SS-31 has advanced into human clinical trials for Barth syndrome (a cardiolipin remodeling disorder), primary mitochondrial myopathy, heart failure with preserved ejection fraction, and age-related macular degeneration, making it one of the most clinically advanced mitochondria-targeted peptide therapeutics. Current investigation continues across cardiac, renal, ophthalmic, skeletal muscle, and neurological applications.
SS-31 binds selectively to cardiolipin through electrostatic interactions between its cationic residues and cardiolipin's anionic phosphate headgroups, stabilizing the phospholipid's interactions with cytochrome c and ETC supercomplexes. Published research demonstrates that this binding prevents cardiolipin peroxidation, maintains proper cristae ultrastructure, and preserves the lipid microdomains essential for efficient electron transfer between Complex III and Complex IV via cytochrome c shuttling.
Unlike conventional antioxidants that scavenge ROS after they are generated, SS-31 reduces mitochondrial ROS production at its source by optimizing electron transport chain efficiency and preventing electron leak at Complexes I and III. Published preclinical studies report 40-60% reductions in mitochondrial superoxide and hydrogen peroxide generation, addressing the root cause of mitochondrial oxidative stress rather than neutralizing its downstream products.
By restoring ETC supercomplex organization and cardiolipin-dependent cytochrome c function, SS-31 improves the coupling efficiency between electron transport and ATP synthesis at Complex V (ATP synthase). Published research in aged animal models demonstrates significant recovery of ATP production capacity in cardiac, skeletal muscle, and renal tissues, with functional improvements in exercise tolerance, cardiac output, and kidney filtration that correlate with restored bioenergetic parameters.
Published research protocols reference daily subcutaneous administration. Store refrigerated at 2-8°C. Consult applicable literature for specific research applications.
Every batch is independently analyzed by a third-party laboratory for purity and identity before release. A batch-specific Certificate of Analysis (COA) is available for each lot.
Purity
99.3%
Lab
Janoshik Analytical Laboratory
Batch
SS31-2025-001
Test Date
2025-03-19
Orders placed before our daily cutoff ship the same business day. Free shipping on orders over $150, with tracking emailed as soon as your order leaves our facility.
Shipment protection covers your order against loss or damage in transit — if a protected order is lost or arrives damaged, our support team will arrange a replacement or resolution.
For in-vitro research and laboratory use only. This product is not a drug, supplement, food, or cosmetic, and has not been evaluated by the FDA.
Use is restricted to qualified researchers and laboratories operating within all applicable institutional, legal, and ethical guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
Our SS-31 (elamipretide) is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) manufactured in FDA-registered, cGMP-compliant facilities in the USA. Each batch undergoes HPLC purity analysis (99%+), mass spectrometry for molecular identity including the non-natural D-arginine and 2',6'-dimethyltyrosine residues, and chiral amino acid analysis. The specific stereochemistry and methylation pattern are critical for cardiolipin binding affinity and mitochondrial targeting.
SS-31 in lyophilized form stored at -20°C remains stable for up to 24 months. The D-arginine residue confers partial protease resistance, enhancing stability compared to all-L-amino acid peptides. Once reconstituted with bacteriostatic water, store at 2-8°C and use within 30 days. SS-31 solutions should be protected from strong light, as the dimethyltyrosine residue can undergo photochemical modification.
Each order includes SS-31 (elamipretide) at the specified dosage in lyophilized form, a Certificate of Analysis (COA) from Janoshik Analytical Laboratory confirming purity and stereochemical identity, and detailed storage and reconstitution instructions. The 5mg vial supports standard daily subcutaneous research protocols referenced in the published mitochondrial medicine literature. Bacteriostatic water is sold separately.
Yes, we offer volume discounts for research institutions conducting mitochondrial function, cardiac, renal, or aging biology research with SS-31. As one of the most clinically advanced mitochondria-targeted peptides, SS-31 is in high demand across multiple research disciplines. Contact support@pepcelllabs.com for wholesale pricing and custom quantities.
SS-31 (elamipretide) is sold strictly for in-vitro research, laboratory use, and educational purposes. While elamipretide has entered multiple Phase II and Phase III human clinical trials for Barth syndrome, primary mitochondrial myopathy, and heart failure (under the pharmaceutical designations Bendavia and MTP-131), this research-grade product is not a pharmaceutical preparation and is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
